Mesenchymal stem cells (MSCs) can be found in many adult tissues and are an attractive stem cell source for the regeneration of damaged tissues in clinical applications because they are characterized as undifferentiated cells, able to self-renew with a high proliferative capacity and that possess differentiation potential. Although bone marrow (BM) has been the main […]
Traumatic spinal cord injury (SCI) has an immediate and catastrophic impact on movement control and on all aspects of a patient’s health and quality of life. Primary trauma injury causes direct damage, which often leads to death of cells, disruption to blood-SC barrier, and degradation of extracellular matrix (ECM). All of these processes cause an […]
When a woman goes to a prenatal visit the physician typically focuses almost exclusively on her behaviors, but new research findings suggest that science should be looking more closely at the father’s behavior as well. Whether maternal background can mitigate sperm-inherited alterations in developmental programming and modify penetrance of growth defects induced by preconception paternal […]
Coronavirus disease 2019 (COVID-19) is a highly infectious epidemic disease that has seriously affected human health worldwide. To date, however, there is still no definitive drug for the treatment of COVID-19. Based on the results of several models and stage-clinical trials ARDS and sepsis, cell-based therapy, especially stem cells therapy has emerged as an alternative […]
Epidemiological studies have demonstrated that breastfeeding has a protective effect against breast cancer. However the mechanism behind this has remained unclear. Studies using mice models suggest that this could be due to changes in breast tissue that occur during breastfeeding causing long lasting epigenetic changes. But the exact mechanism has been difficult to investigate because […]
Being obese and overweight can increase the risk of developing multiple health conditions including hypertension, cardiovascular disease, and type 2 diabetes. According to studies excess weight can also cause a chronic inflammatory state in the body. Obesity is associated with this increased inflammatory state in which there is an increase in markers of inflammation and […]
Mesenchymal stem cells (MSCs) transplantation is undergoing extensive research as cellular therapy for human clinical trials. Because they can be easily isolated and expanded in vitro there is a natural desire to test MSCs in many diverse clinical indications. Mesenchymal stem cells can differentiate into different lineages, and they produce many cytokines and growth factors […]
Patients suffering from severe COVID-19 exhibit multisystem organ failure involving not only pulmonary but also cardiovascular, neural, and other systems. The complexity of the organ system failures both complicate the care of COVID-19 patients and contribute, to a great extent, to the morbidity and mortality of the pandemic. A study from researchers at Columbia University […]
Malignancies and cancer account for a quarter of human death cases. Lung, prostate, breast and colorectal cancers are the ones that cause the majority of cancer related deaths. The typical therapeutics include surgery, chemotherapy, and radiotherapy. Although the methods for treating the malignancies and curing the cancer patients have greatly been improved in recent years, […]
Mammals began consuming alcohol from fermented fruit long before humans developed methods to produce alcohol from distillation. Excessive alcohol consumption is a major health and social issue globally. Recently a group of researchers has found the role of a hormone in alcohol addiction. The study was published in the journal Cell Metabolism. There have been […]