Category Archives: Regenerative Medicine News and General Information

Metformin is the standard first-line pharmaceutical intervention for type 2 diabetes mellitus (T2D), and is one of the most widely prescribed drugs worldwide. Metformin has glucose-lowering effects in patients with T2D.  After it is given orally, the medication accumulates to a high degree within the liver due to first-pass uptake in the portal vein following […]

Acetaminophen has been always considered as a safer alternative to Nonsteroidal Anti Inflammatory Drugs (NSAIDs), and their use regarding blood pressure and cardiovascular health.  This medication is widely used as first-line therapy for chronic pain because of this perceived safety and the assumption that, unlike NSAIDs, it has little or no effect on the blood […]

More than 1 million children become ill with tuberculosis annually, and almost 20% of them die, but children have historically been excluded from clinical efficacy trials of antituberculosis treatment.  This situation is due in part to low rates of bacteriologic confirmation of disease among children, given high rates of paucibacillary disease and difficulties in obtaining […]

Someone in the world develops dementia every 3 seconds. There are over 55 million people worldwide living with dementia in 2020. This number will almost double every 20 years, reaching 78 million in 2030 and 139 million in 2050. Much of the increase will be in developing countries.  Research shows that most people currently living […]

Adult cells in the body can only give rise to the same cell type. One example is skin cells, they cannot give rise to a muscle cell but to skin cells only. During early development the cells in the embryo can generate all cell types of our body, including stem cells. This capacity is called […]

Obstructive sleep apnea (OSA) affects more than 22 million people in the United States and is linked to a higher risk of multiple health conditions, including hypertension, heart attacks, stroke and diabetes, which are also among the first causes of death. Researchers from the University of Missouri School of Medicine have found that untreated OSA […]

Physical fitness is important for survival. Lack of physical activity results in detraining, lower performance, and ultimately, incapacity.  Exercise is commonly encouraged, even prescribed, as therapy. We know that if every human could maintain a suitable level of exercise and fitness, many disease problems would be less severe and quality of life would be better. […]

Faecal microbiota transplantation (FMT) has a lengthy history dating back to the fourth century AD in China, where it was used to treat conditions such as diarrhea and food poisoning.  Its contemporary salience reflects awareness that  the  gastrointestinal  tract  is  an  ecosystem  of  bacteria  and  other  microorganisms  (i.e.,  the  gut  microbiome)  which,  either  by  themselves […]

Cytokines are soluble molecular messengers that activate and propagate disease-fighting immune cascades in the body in response to stimuli from antigen-presenting cells.  In cancer immunotherapy, exogenous cytokines initiate immune system activation to optimize the magnitude and nature of the acquired antitumor immune response. Many proinflammatory cytokines including interleukin-2 (IL2), IL7, IL12, IL15, and interferon-γ have […]

Antimicrobial resistance is a major healthcare crisis. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of healthcare associated infections, pneumonia and skin and soft tissue infections.  Antifolates such as trimethoprim (TMP) exhibit potent activity as antibacterial agents against many MRSA clinical isolates, and due to structural and sequence differences between human and prokaryotic […]