Malnutrition Early in Life Sets Stage for Poor Growth and Early Death

In 2022, more than one in five children around the world did not get enough calories to grow normally, and more than 45 million showed signs of wasting, or weighing too little for their height. More than a million children die each year as a consequence of wasting and more than 250,000 die from stunting. People who experienced stunting and wasting in childhood may also experience worse cognitive development, which translates into worse economic outcomes as adults.

Stunting, or being too short for their age, indicates chronic malnutrition, while wasting measures acute malnutrition. The global health community uses both indications to monitor progress toward ending malnutrition.

“Children whose growth begins to falter before they are six months old are much more likely to die and much more likely to have severe forms of growth faltering by the time they’re 18 to 24 months old,” said the papers’ senior author, Benjamin Arnold, PhD, MPH. “This suggests there is a very narrow period in which we can intervene, ideally in the prenatal period. It also suggests broader interventions are needed to improve nutrition among women of childbearing age.”

The analysis involved an international team of more than 100 researchers led by UC Berkeley that examined data on nearly 84,000 children under two years old from 33 major studies that began between 1987 and 2014. The cohorts came from 15 countries in South Asia, Sub-Saharan Africa, Latin America and Eastern Europe.

While some children can catch up with improvements to their health and nutrition, the earlier onset of growth faltering revealed in this research suggests that public health interventions should expand their focus to include children under 6 months old and pregnant mothers.

Currently, most childhood nutritional interventions begin after about six months of age because they often include nutritional supplementation, and public health programs don’t want to interfere with breastfeeding.

“Our findings suggest that if health interventions are not delivered before age six months, it is too late to prevent stunted growth for about a third of children in the populations represented in this study and as many as half of children in South Asia,” said Jade Benjamin-Chung, PhD, MPH.

The papers also highlight the need to provide nutritional and health support to women before conception, and to continue that support during and after pregnancy. In the studies, the researchers observed that a malnourished mother is likely to give birth to a child who will repeat that cycle of malnutrition into the next generation.

Sources:

Jade Benjamin-Chung, Andrew Mertens, John M. Colford, Alan E. Hubbard, Mark J. van der Laan, Jeremy Coyle, Oleg Sofrygin, Wilson Cai, Anna Nguyen, Nolan N. Pokpongkiat, Stephanie Djajadi, Anmol Seth, Wendy Jilek, Esther Jung, Esther O. Chung, Sonali Rosete, Nima Hejazi, Ivana Malenica, Haodong Li, Ryan Hafen, Vishak Subramoney, Jonas Häggström, Thea Norman, Kenneth H. Brown, Parul Christian, Benjamin F. Arnold, Souheila Abbeddou, Linda S. Adair, Tahmeed Ahmed, Asad Ali, Hasmot Ali, Per Ashorn, Rajiv Bahl, Mauricio L. Barreto, France Begín, Pascal Obong Bessong, Maharaj Kishan Bhan, Nita Bhandari, Santosh K. Bhargava, Zulfiqar A. Bhutta, Robert E. Black, Ladaporn Bodhidatta, Delia Carba, Ines Gonzalez Casanova, William Checkley, Jean E. Crabtree, Kathryn G. Dewey, Christopher P. Duggan, Caroline H. D. Fall, Abu Syed Golam Faruque, Wafaie W. Fawzi, José Quirino da Silva Filho, Robert H. Gilman, Richard L. Guerrant, Rashidul Haque, Sonja Y. Hess, Eric R. Houpt, Jean H. Humphrey, Najeeha Talat Iqbal, Elizabeth Yakes Jimenez, Jacob John, Sushil Matthew John, Gagandeep Kang, Margaret Kosek, Michael S. Kramer, Alain Labrique, Nanette R. Lee, Aldo Ângelo Moreira Lima, Mustafa Mahfuz, Tjale Cloupas Mahopo, Kenneth Maleta, Dharma S. Manandhar, Karim P. Manji, Reynaldo Martorell, Sarmila Mazumder, Estomih Mduma, Venkata Raghava Mohan, Sophie E. Moore, Ishita Mostafa, Robert Ntozini, Mzwakhe Emanuel Nyathi, Maribel Paredes Olortegui, William A. Petri, Prasanna Samuel Premkumar, Andrew M. Prentice, Harshpal Singh Sachdev, Kamran Sadiq, Rajiv Sarkar, Naomi M. Saville, Saijuddin Shaikh, Bhim P. Shrestha, Sanjaya Kumar Shrestha, Alberto Melo Soares, Bakary Sonko, Aryeh D. Stein, Erling Svensen, Sana Syed, Fayaz Umrani, Honorine D. Ward, Keith P. West, Lee Shu Fune Wu, Seungmi Yang, Pablo Penataro Yori. Early-childhood linear growth faltering in low- and middle-income countries. Nature, 2023; DOI: 10.1038/s41586-023-06418-5

Andrew Mertens, Jade Benjamin-Chung, John M. Colford, Alan E. Hubbard, Mark J. van der Laan, Jeremy Coyle, Oleg Sofrygin, Wilson Cai, Wendy Jilek, Sonali Rosete, Anna Nguyen, Nolan N. Pokpongkiat, Stephanie Djajadi, Anmol Seth, Esther Jung, Esther O. Chung, Ivana Malenica, Nima Hejazi, Haodong Li, Ryan Hafen, Vishak Subramoney, Jonas Häggström, Thea Norman, Parul Christian, Kenneth H. Brown, Benjamin F. Arnold, Souheila Abbeddou, Linda S. Adair, Tahmeed Ahmed, Asad Ali, Hasmot Ali, Per Ashorn, Rajiv Bahl, Mauricio L. Barreto, France Begín, Pascal Obong Bessong, Maharaj Kishan Bhan, Nita Bhandari, Santosh K. Bhargava, Zulfiqar A. Bhutta, Robert E. Black, Ladaporn Bodhidatta, Delia Carba, Ines Gonzales Casanova, William Checkley, Jean E. Crabtree, Kathryn G. Dewey, Christopher P. Duggan, Caroline H. D. Fall, Abu Syed Golam Faruque, Wafaie W. Fawzi, José Quirino da Silva Filho, Robert H. Gilman, Richard L. Guerrant, Rashidul Haque, Sonja Y. Hess, Eric R. Houpt, Jean H. Humphrey, Najeeha Talat Iqbal, Elizabeth Yakes Jimenez, Jacob John, Sushil Matthew John, Gagandeep Kang, Margaret Kosek, Michael S. Kramer, Alain Labrique, Nanette R. Lee, Aldo Ângelo Moreira Lima, Mustafa Mahfuz, Tjale Cloupas Mahopo, Kenneth Maleta, Dharma S. Manandhar, Karim P. Manji, Reynaldo Martorell, Sarmila Mazumder, Estomih Mduma, Venkata Raghava Mohan, Sophie E. Moore, Ishita Mostafa, Robert Ntozini, Mzwakhe Emanuel Nyathi, Maribel Paredes Olortegui, William A. Petri, Prasanna Samuel Premkumar, Andrew M. Prentice, Harshpal Singh Sachdev, Kamran Sadiq, Rajiv Sarkar, Naomi M. Saville, Saijuddin Shaikh, Bhim P. Shrestha, Sanjaya Kumar Shrestha, Alberto Melo Soares, Bakary Sonko, Aryeh D. Stein, Erling Svensen, Sana Syed, Fayaz Umrani, Honorine D. Ward, Keith P. West, Lee Shu Fune Wu, Seungmi Yang, Pablo Penataro Yori. Child wasting and concurrent stunting in low- and middle-income countries. Nature, 2023; DOI: 10.1038/s41586-023-06480-z

University of California – San Francisco. “Malnutrition early in life sets stage for poor growth and early death.” ScienceDaily. ScienceDaily, 13 September 2023. <www.sciencedaily.com/releases/2023/09/230913161752.htm>.

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