Signs of Aging Reversed in Mice During New Study

In a new study, researchers altered a method by which they reversed the signs of aging in mice, and did so over a longer period of time. They safely reversed various signs of aging in the mice. The results appear in the journal Nature Aging. 

Currently, 16% of the United States population is 65 years or older. By 2050 this is expected to reach 22%.

The National Institute on AgingTrusted Source points out that there are various things a person can do to help reduce the effects of aging.

These include staying physically active, eating a healthy diet with lots of vegetables, fruit, and whole grains, getting a good amount of quality sleep, avoiding smoking and drinking alcohol, and regularly seeing a doctor.

The same researchers found in a previous study that some epigenetic markers could be reprogrammed using the molecules Oct4, Sox2, Klf4, and cMyc, which are known as Yamanaka factors, and are known to increase the lifespan and reduce the effects of aging in mice. 

Current Study Results

During the current study, the researchers used 3 groups of mice, one of which received the Yamanaka factors from 15 to 22 months (50-70 years in human terms), a second group received the factors form 12 to 22 months (35-70 years in human terms), and a third group who received them for a single month at 25 months (80 years in human terms). 

The team observed that those mice receiving the factors did not develop cancer or see blood cell or neurological changes. They also saw that the mice skin looked younger, had better wound healing, and did not have typical aging related signs. 

According to the researchers their findings provide exciting information, which could someday be used to develop these same strategies in human models. 


Timothy Huzar. (2022, Mar 31). Signs of aging safely reversed in mice. Medical News Today. Retrieved from: 

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