In a recently published study, researchers evaluated the use of cerebrospinal fluid (CSF) transferred from younger to older mice and its effect on the aging brain. The study appears in the journal Nature. For the study, the researchers conditioned mice to remember an event so they could test this memory later. They used 20-month-old mice […]
Animal studies have demonstrated that diets that severely restrict total calorie intake while providing all the essential nutrients can extend the average lifespan. Animal studies have revealed that the timing of calorie restriction can have an effect due to the circadian system, which controls daily cycles of physiology, metabolism, and behaviors such as eating. This […]
Aging is characterized by declining cell, tissue, and organ function and increased susceptibility to chronic and debilitating diseases. Comprising bacteria, viruses, fungi, protozoa, and archaea, the intestinal microbiota contributes to the life-long health of the host, playing key roles in the development and maintenance of the host immune system and the intestinal epithelial barrier. During […]
Aging is a complex and intraindividual process, usually defined as a time-dependent progressive loss of the individual’s physiological integrity, which eventually leads to deteriorated physical function. The accumulated molecular and cellular damage across an individual’s life span often leads to age-associated pathological conditions and thus makes them more prone to disease and death. Despite hundreds […]
Aging is a natural biological process that affects every cell in our bodies, resulting in various age-related pathologies, and finally the death of each multicellular organism. It is a complicated and multifactorial process, in which different mechanisms participate, including mitochondrial dysfunction, lysosome processing, endoplasmic reticulum stress, genomic instability, telomere attrition, epigenetic alterations, stem cell exhaustion, […]
Selenium is an essential trace mineral found in soil, water, and some foods. It is an important factor in many body processes. Studies have suggested that it has anti-aging properties and may even protect against age-related diseases. This mineral is naturally present in the body, it gets stored in muscle tissue, though the thyroid is […]
Researchers from the Braham Institute have developed a method to “time jump” human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. The team was able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The study was […]
In a new study, researchers altered a method by which they reversed the signs of aging in mice, and did so over a longer period of time. They safely reversed various signs of aging in the mice. The results appear in the journal Nature Aging. Currently, 16% of the United States population is 65 years […]
The factors responsible for increasing length of life are not well understood. Identifying effective interventions to increase lifespan remains a challenge. Clues to unravel the mystery of longevity come from factors identified as contributors to the biology of the aging process such as elevated oxidative stress and mitochondrial dysfunction. The elevated oxidative stress is toxic […]
Having an advanced age is the largest risk factor for impairde mental and physical function and many non-communicable diseases including cancer, neurodegenerative diseases, type 2 diabetes, and cardiovascular disease. DNA methylation is the addition of a methyl group to cytosine residues at selective areas on a chromosome. This process can readily and cheaply be mapped […]