Tiny Magnetic Particles in Air Pollution Linked to Development of Alzheimer’s

Magnetite, a tiny particle found in air pollution, can induce signs and symptoms of Alzheimer’s disease, new research suggests.

Alzheimer’s disease, a type of dementia, leads to memory loss, cognitive decline, and a marked reduction in quality of life. It impacts millions globally and is a leading cause of death in older individuals.

The study, Neurodegenerative effects of air pollutant particles: Biological mechanisms implicated for early-onset Alzheimer’s disease, led by Associate Professor Cindy Gunawan and Associate Professor Kristine McGrath from the University of Technology Sydney (UTS) was recently published in Environment International.

The research team, from UTS, UNSW Sydney and the Agency for Science, Technology and Research in Singapore, examined the impact of air pollution on brain health in mice, as well as in human neuronal cells in the lab.

Their aim was to better understand how exposure to toxic air pollution particles could lead to Alzheimer’s disease.

The researchers exposed healthy mice and those genetically predisposed to Alzheimer’s to very fine particles of iron, magnetite, and diesel hydrocarbons over four months. They found that magnetite induced the most consistent Alzheimer’s disease pathologies.

This included the loss of neuronal cells in the hippocampus, an area of the brain crucial for memory, and in the somatosensory cortex, an area that processes sensations from the body. Increased formation of amyloid plaque was seen in mice already predisposed to Alzheimer’s.

The researchers also observed behavioural changes in the mice that were consistent with Alzheimer’s disease including increased stress and anxiety and short-term memory impairment, the latter particularly in the genetically predisposed mice.

The researchers found that magnetite induced an immune response in the mice and in the human neuronal cells in the lab. It triggered inflammation and oxidative stress, which in turn led to cell damage. Inflammation and oxidative stress are significant factors known to contribute to dementia.

The results will be of interest to health practitioners and policymakers. It suggests that people should take steps to reduce their exposure to air pollution as much as possible, and consider methods to improve air quality and reduce the risk of neurodegenerative disease.

The study has implications for air pollution guidelines. Magnetite particles should be included in the recommended safety threshold for air quality index, and increased measures to reduce vehicle and coal-fired power station emissions are also needed.

Sources:

Cindy Gunawan, Charlotte Fleming, Peter J. Irga, Roong Jien Wong, Rose Amal, Fraser R. Torpy, S. Mojtaba Golzan, Kristine C. McGrath. Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease. Environment International, 2024; 185: 108512 DOI: 10.1016/j.envint.2024.108512

University of Technology Sydney. (2024, February 29). Tiny magnetic particles in air pollution linked to development of Alzheimer’s. ScienceDaily. Retrieved March 7, 2024 from www.sciencedaily.com/releases/2024/02/240229182937.htm

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