Viruses Discovered as New Therapy Option

Up to 15 percent of children and five percent of adults are affected by the chronic inflammatory skin disease atopic dermatitis. Despite advanced therapy measures, the severe itching and eczema, especially on the elbows or knees, cause great distress to the patients. 

In the course of a study conducted at MedUni Wien a research team led by Wolfgang Weninger, Head of the Department of Dermatology, has discovered a new approach: bacteriophages, which colonize the skin as viral components of the microbiome and can drive the development of innovative atopic dermatitis therapies. 

The research results were recently published in the scientific journal Science Advances.

Until now, the importance of bacteriophages (“bacteria eaters,” also called phages) in the human body has been known primarily from analyses of the intestine. In the search for innovative therapeutic measures for atopic dermatitis (AD), the MedUni Vienna research team has now investigated the interaction of phages and bacteria in the skin for the first time. After all, it has long been known that the progression of AD is accompanied by massive changes in the skin microbiome. 

The microbiome is the sum of all microorganisms on the skin and has been primarily investigated for its bacterial constituents. It has been unknown whether viruses also contribute to the nature of the bacterial microbiome in healthy and diseased skin. Phages are viruses of different types and functions whose sole aim is to infect bacteria, thereby either destroying them — or stimulating them to multiply.

The resulting shift in the balance between phages and bacteria was not detected in the comparative samples from healthy individuals and may be one explanation for the overpopulation of the skin microbiome with bacteria called Staphylococcus aureus found in AD. 

These findings contribute significantly to a better understanding of the skin bioflora in AD patients and pave the way for the development of new targeted therapeutic interventions: By identifying and culturing phages specialized for Staphylococcus aureus, a promising new option is available.

While that makes it a challenge for scientists to identify the type of phage needed for a particular purpose, it also enables them to use them in a targeted manner. 

Bacterial viruses do not make any difference between antibiotic-resistant and other bacteria, thus they are being researched as possible weapon in the fight against multi-resistant pathogens. Further studies are now planned to confirm phage therapy for topical use in atopic dermatitis.

Sources:

M. Wielscher, K. Pfisterer, D. Samardzic, P. Balsini, C. Bangert, K. Jäger, M. Buchberger, B. Selitsch, P. Pjevak, B. Willinger, W. Weninger. The phageome in normal and inflamed human skin. Science Advances, 2023; 9 (39) DOI: 10.1126/sciadv.adg4015

Medical University of Vienna. (2023, September 29). Atopic dermatitis: Viruses discovered as new therapy option. ScienceDaily. Retrieved October 2, 2023 from www.sciencedaily.com/releases/2023/09/230929170958.htm 

Photo by Angela Roma from Pexels: https://www.pexels.com/photo/skin-surface-with-pigmentation-spot-in-center-7479970/