Pulmonary fibrosis (PF) is a chronic, life-threatening disease with a gradual worsening of pulmonary function and shortness of breath, and the median survival time of patients with idiopathic pulmonary fibrosis (IPF) was estimated to be 2.5–3.5 years. Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened, stiff tissue […]
Achondroplasia (ACH) is the most common genetic form of short-limb dwarfism. Is an autosomal dominant monogenic disorder (MGD) caused by a gain-of-function point mutation in the transmembrane region of fibroblast growth factor receptor 3 (FGFR3). Currently there are two mutation sites reported, Gly380Arg and Gly375Cys, and the former occupies a vast majority of ACH patients. […]
Crohn’s disease (CD) is a type of inflammatory bowel disease (IBD). It causes inflammation of the digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn’s disease can involve different areas of the digestive tract in different people. This inflammation often spreads into the deeper layers […]
A new study shows that people who eat a diet that includes at least half a serving per day of foods high in flavonoids like strawberries, oranges, peppers and apples may have a 20% lower risk of cognitive decline. The research was published in the journal Neurology, the medical journal of the American Academy of […]
Children of all ages can become ill with coronavirus disease 2019 (COVID-19). But most kids who are infected typically don’t become as sick as adults and some might not show any symptoms at all. According to the American Academy of Pediatrics and the Children’s Hospital Association, in the U.S. children represent about 13% of all […]
Immune system T cells have been reprogrammed by a group of researchers from the Georgetown Lombardi Comprehensive Cancer Center into regenerative stem cell-like memory cells (TSCM) that are long-lived, highly active “super immune cells” with strong antitumor activity. Cancer immunotherapy, also known as immuno-oncology, is a form of cancer treatment that uses the power of […]
Most developing and adult tissues are hierarchically organized such that tissue growth and maintenance are driven by the production of lineage-committed cells from populations of tissue-resident stem and progenitor cells. Stem cells in adult tissues are typically found in a quiescent or reversible G0 state and must re-enter the cell cycle and divide to promote […]
Microbes that live in our gut don’t just digest food. They also have far-reaching effects on the immune system. A new study shows that a particular gut microbe can prevent severe flu infections in mice, likely by breaking down naturally occurring compounds, called flavonoids, commonly found in foods such as black tea, red wine, blueberries […]
Currently, there are more than 50 million Americans aged 65 years or more, and that is projected to more than double by 2060. A consequence of this increase in older adults is the escalation of age-related diseases. Alzheimer’s disease (AD) and related dementias, a group of symptoms in which there is progressive deterioration in cognitive […]
Researchers at the Princess Margaret Cancer Centre have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers. The team of researchers studied lysosomes, which are membrane-bound organelles found in all cells. They were once believed […]