In some diseases, the underlying processes can start years before a diagnosis is made. A new study finds that people who later develop multiple sclerosis (MS) are more likely to have conditions like depression, constipation and urinary tract infections five years before their MS diagnosis than people who do not develop MS. The conditions were […]
3D eye scans can reveal vital clues about kidney health that could help to track the progression of disease, research suggests. Researchers used highly-magnified images to detect changes to the retina — the layer of tissue at the back of the eye that senses light and sends signals to the brain. They found that the […]
Disease of the small airways in the lungs is a potential long-lasting effect of COVID-19, according to a new study. The study found that small airways disease occurred independently of initial infection severity. The long-term consequences are unknown. “There is some disease happening in the small airways independent of the severity of COVID-19,” said study […]
Many individuals with kidney dysfunction develop anemia, or a shortage of healthy red blood cells that carry oxygen to the body’s tissues. Some treatments for anemia are linked with serious cardiovascular side effects, but a new class of oral drugs called hypoxia inducible factor-prolyl hydroxylase inhibitors may be comparable to placebo in these trials. These […]
A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, eczema and other chronic disorders, new research from The Australian National University (ANU) has found. The discovery could pave the way […]
MS is a progressive neurological disease that currently has no cure. It is associated with a wide-range of debilitating symptoms, including problems with coordination, cognition, muscle weakness and depression. CAMH-led pre-clinical studies using a small molecule drug have shown promise as a potential new treatment for multiple sclerosis (MS). Expanding on Dr. Fang Liu’s earlier […]
Comparing PET scans of more than 90 adults with and without mild cognitive impairment (MCI), Johns Hopkins Medicine researchers say relatively lower levels of the so-called “happiness” chemical, serotonin, in parts of the brain of those with MCI may play a role in memory problems including Alzheimer’s disease. “The study shows that people with mild […]
A preclinical study shows that a specific human genetic variant of a receptor that stimulates insulin release may help individuals be more resistant to obesity. The study provides new insight into how human genetic variations affect an individual’s susceptibility to weight gain. The researchers developed mice with a human genetic variant in the glucose-dependent insulinotropic […]
Microgels form a thin protective shell around a droplet until the temperature rises above 32 degrees. Then the microgels shrink and the droplet dissolves in the surrounding liquid. A study now reveals the underlying mechanism behind this process. The discovery could revolutionize methods of targeting medicines to specific locations within the body. Emulsions consist of […]
Researchers discovered distinct mechanisms controlling different types of immune cells, and found that, by precisely targeting these mechanisms, they could selectively eliminate ‘problematic cells’ and reshape the skin’s immune landscape. Our skin is packed with specialized immune cells that protect against infections and cancer and promote healing. These cells, called tissue-resident T cells or TRM […]