Bioengineers Examine Cellular Breakdown: How Ultraviolet Radiation Can Alter the Microstructure of Human Skin

A study from Binghamton University researchers recently published in the Journal of the Mechanical Behavior of Biomedical Materials explores how ultraviolet radiation can alter the microstructure of human skin making it appear  “leathery”. Particularly affected is collagen, the fibrous protein that binds together tissue, tendon, cartilage and bone throughout our bodies.

“We don’t want to put a fear factor in here saying ‘don’t go out in the sun,'” said Binghamton University Associate Professor of Biomedical Engineering Guy German. “But extended periods of time under UV light can toughen up your skin as well as lead to a higher risk of carcinogenic problems.”

The new study builds on previous research from German and Lipsky that focused on the outer stratum corneum, which is the top layer of skin. This time, the Binghamton team compared full-thickness skin samples before and after various levels of UV exposure.

“One way to characterize the material characteristics of skin is by conducting a mechanical stretch test on it,” Ittycheri said. “If it stretches very easily, it’s relatively compliant, but if it’s much harder to stretch it, you can characterize it as much stiffer. My experiment was to see what the isolated effects of UV light would be and compare it with a scenario where a skin is not exposed to UV light.”

The researchers found that as the skin absorbed more UV radiation, the collagen fibers in it became more tightly packed together, leading to increased stiffness and tissue that is harder to break. German sees correlations with the cross?linkage theory of aging, which proposes that the accumulation of undesirable molecular bonds over time can cause cellular dysfunction.

Hookway sees similarities between how heart and skin cells deal with damage, even though they have very different functions.

“Our body has this natural response in any tissue when there’s some sort of injury, which likely happens in the stratum corneum,” she said. “First, wherever there’s some sort of weakening, there has to be compensation by some other part of the tissue or else there’ll be catastrophic failure. Same thing happens in the heart when you have a myocardial infarction — you build up a scar and your heart’s going to not work the same way anymore.”

“Any kind of disruption to the normal process of skin is going to be extremely dangerous and detrimental to our overall lifestyle,” Ittycheri said. “That’s not even going into the cosmetic side of things, where a person’s perception about themselves can be challenged when their skin does not look good.”


Abraham Ittycheri, Zachary W. Lipsky, Tracy A. Hookway, Guy K. German. Ultraviolet light induces mechanical and structural changes in full thickness human skin. Journal of the Mechanical Behavior of Biomedical Materials, 2023; 143: 105880 DOI: 10.1016/j.jmbbm.2023.105880

Binghamton University. “Why does skin get ‘leathery’ after too much sun? Bioengineers examine cellular breakdown: When exposed to too much ultraviolet radiation, collagen fibers become more tightly packed together.” ScienceDaily. ScienceDaily, 19 July 2023. <>.

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Photo by Jonathan Borba