Redox and metabolic mechanisms lie at the heart of stem cell survival and regenerative activity. NRF2 is a major transcriptional controller of cellular redox and metabolic homeostasis, which has also been implicated in ageing and lifespan regulation. However, NRF2’s role in stem cells and their functioning with age is only just emerging. The importance of […]
How aging contributes to bone loss is unclear. In aging mice, skeletal stem cells lose their ability to generate bone-forming cells called osteoblasts, and instead promote the generation of bone-resorbing cells called osteoclasts. Aging is a key driver of bone-mass reductions and skeletal fragility. Insights into the identity of skeletal stem cells (SSCs) and other […]
Neural stem cells are largely undifferentiated cells originating in the central nervous system. Neural stem cells (NSCs) have the potential to give rise to offspring cells that grow and differentiate into neurons and glial cells (non-neuronal cells that insulate neurons and enhance the speed at which neurons send signals). For years it was thought that […]
Our body is made up of millions of cells. As we age our cells do the same and there is a point when they stop replicating and dividing until they eventually die. Scientists have long known that genes influence how cells age and how long humans live, but the exact mechanism remains unknown. A new […]