As the population continues to age, a pandemic of Parkinson’s disease (PD) is emerging, with conservative estimates of over 14 million victims globally by 2040. While PD patients display a wide range of non-motor features, the defining symptoms are progressive motor deficits due to striatal dopaminergic insufficiency secondary to loss of dopaminergic nigral neurons. Current […]
Category Archives: Stem Cell Therapy for Specific Conditions
Knee osteoarthritis (KOA) is a common condition affecting the adult population and resulting in a negative impact on quality of life. It is more prevalent in individuals older than 65 years. An estimated 9–14 million adults in the USA alone suffer from KOA. However, the prevalence is increasing among patients younger than 65 years. As […]
Mesenchymal stem cells (MSCs) differentiate into different cell types and have immunomodulatory and paracrine effects. These cells can be obtained from different adult tissues, including the umbilical cord, which is an excellent source of MSCs. This tissue can be obtained during vaginal or cesarean delivery without risk for neither the baby nor the mother. There […]
Different studies have shown good results with the intravenous administration of mesenchymal stem cells derived from different sources, such as bone marrow, adipose tissue, and umbilical cord. They have been reported to be effective, safe, and promising in the recovery and clinical outcomes of stroke patients at acute and subacute stages, but clinical studies at […]
Type 2 diabetes mellitus (T2DM) is a heterogeneous syndrome that is characterized by a progressive deterioration in glycemic control caused by decreased insulin sensitivity and diminished insulin secretion, which has become a serious threat to human health worldwide due to its high prevalence and severe morbidity. Diet, physical exercise, and glucose-lowering medications have been shown […]
Aging is a natural biological process that affects every cell in our bodies, resulting in various age-related pathologies, and finally the death of each multicellular organism. It is a complicated and multifactorial process, in which different mechanisms participate, including mitochondrial dysfunction, lysosome processing, endoplasmic reticulum stress, genomic instability, telomere attrition, epigenetic alterations, stem cell exhaustion, […]
Cerebral palsy (CP) is a neurological insufficiency that results from brain injury occurring before full neurological development. It involves impairment of movement, muscle, and cognitive functions. The condition can be also accompanied by impairments in speech, cognition, epilepsy, secondary muscle contraction, and limb deformity. Current progress in regenerative medicine has confirmed that stem cells can […]
What is Ulcerative Colitis? Ulcerative colitis (UC) is a major form of inflammatory bowel disease (IBD), characterized by chronic inflammation and ulcers of the colonic mucosa with variable extension from the rectum toward the cecum. The etiology of the disease is complicated and the major pathogenic mechanism is the uncontrolled activation of innate and adaptive […]
Diabetes mellitus is a chronic disease that affects over 460 million people worldwide (International Diabetes Foundation, 2019) and bears a significant financial, disability, and mortality cost for health care systems and patients globally. Almost 130,000 new cases of type 1 diabetes are diagnosed each year, and patients face a lifetime of exogenous insulin therapy. Approximately […]
In recent decades, mesenchymal stem cells (MSCs) in cell-based therapy have spanned across various diseases in experimental and clinical research worldwide, exhibiting therapeutic efficacy over conventional treatments due to their distinctive biological properties. You can isolate them from perinatal tissues, such as the umbilical cord, umbilical cord blood and placenta, and multiple biological tissues in […]