Phthalates and Brain Development

Children whose mothers had a higher exposure to certain phthalates during pregnancy tend to show smaller total gray matter in their brains at age 10. This is one of the main conclusions of a study led by the NYU Grossman School of Medicine and the Barcelona Institute for Global Health (ISGlobal), a centre supported by the “la Caixa” Foundation, and published in Molecular Psychiatry.

The study also found that maternal exposure to plasticizers during pregnancy is associated with lower child IQ at age 14, which confirmed the results of two previous study on the topic. Moreover, the research team observed that this relationship between exposure to certain phthalates and lower child IQ is partially influenced by total gray matter volumes. In other words: exposure to plasticizers before birth could lead to smaller total gray matter in childhood, which in turn could be related to a lower IQ.

Finally, the results showed an association between gestational exposure to plasticizers and smaller white matter volumes in girls.

Phthalates are a group of chemicals which are ubiquitously used as plasticizers and solvents in a wide range of commercial products, such as personal care products, food packaging or vinyl flooring. Previous studies have shown that certain phthalates are associated with less optimal cognitive function, social development, and motor skills as well as behavioral problems in children.

In order to provide new evidences, the authors used data from 775 mother-child pairs from Generation R, a pediatric neuroimaging cohort based in Rotterdam (The Netherlands). Phthalate exposure of mothers was assessed using urine samples collected during pregnancy. Since phthalates are difficult to detect due to their rapid decay in the human body, the analysis of the samples focused on detecting phthalate metabolites, the breakdown products generated as the consequence of the presence phthalates.

The statistical analysis revealed an association between higher gestational concentrations of monoethyl phthalate (mEP) and smaller total gray matter volumes in offspring at age 10. mEP is a metabolite, or breakdown product, of diethyl phthalate, a compound used to make plastics more flexible and in cosmetic products.

In 2020 and 2021, the Generation R Study reported that maternal prenatal urinary concentrations of phthalates were associated with lower non-verbal IQ at age 6 years. After showing that the association persists at age 14, the authors state that “the impact of phthalate exposure on the brain and child cognition continues into adolescence.”

The new study estimates that 18% of the total effect of phthalate exposure in pregnancy on children’s IQ could be explained by changes in gray matter volumes in both boys and girls. In girls, the association between gestational exposure to mIBP and lower IQ was found to be due to smaller cerebral white matter in a proportion of 76%.


Akhgar Ghassabian, Michiel van den Dries, Leonardo Trasande, Sander Lamballais, Suzanne Spaan, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Stephanie M. Engel, Anjoeka Pronk, Tonya White, Henning Tiemeier, Mònica Guxens. Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth. Molecular Psychiatry, 2023; DOI: 10.1038/s41380-023-02225-6

Barcelona Institute for Global Health (ISGlobal). (2023, September 20). Exposure to plasticizers in pregnancy associated with smaller volumetric measures in the brain and lower IQ in children. ScienceDaily. Retrieved September 22, 2023 from

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