Aging is one of the biggest risk factors for chronic diseases, including cardiovascular diseases, metabolic disorders, neurodegenerative pathologies and diverse types of cancers. In recent years, big progress has been made to develop agents to treat individual age-related conditions, such as diabetes, osteoporosis, skeletal fragility and vascular dysfunction. However, the effect has been modest. Several […]
Cardiovascular disease is a major target for many experimental stem cell-based therapies and mesenchymal stem cells (MSCs) are widely used in these therapies. Experimental and clinical observations indicate that transplanted MSCs secrete factors to reduce tissue injury and/or enhance tissue repair. Stem Cells in the Treatment of Acute Myocardial Infarction Acute myocardial infarction (AMI) is […]
Sildenafil, more commonly known as viagra, is a medication used to treat erectile dysfunction in men. It is also used to improve the ability to exercise in adults with pulmonary arterial hypertension. A new study published in the journal Nature Aging looked at the potential of repurposing licensed drugs for the treatment of Alzheimer’s disease […]
The COVID-19 pandemic has taken a heavy toll on the health of populations globally. Risk factors for severe and fatal disease are well recognised, and included male sex, black or Asian ethnic origin, obesity, deprivation and a range of comorbidities including diabetes mellitus, cardiovascular disease, COPD and hypertension. There is growing evidence for population-based studies […]
What is Cerebral Palsy? Cerebral palsy (CP) is a group of disorders that affect movement and muscle tone or posture. It’s caused by damage that occurs to the immature, developing brain, most often before birth. It is one of the leading causes of childhood disability and affects the individual’s development and ability to function. CP […]
Despite their questionable efficacy for chronic pain, prescription opioid analgesics have been a mainstay in clinical pain over the last 3 decades. The severity and scale of the North American opioid overdose epidemic has highlighted the genuine risk of physical dependence and overdose with prescription opioids and these risks have been exacerbated by the COVID-19 […]
Regular physical (PA) activity is strongly associated with risk reductions of noncommunicable diseases and mortality. The 2020 World Health Organization Physical Activity Guidelines recommend adults to perform at least 150 minutes/week of moderate intensity PA, or 75 minutes/week of vigorous intensity PA, or an equivalent combination of the 2. Data from the general population indicate […]
What is L-Carnitine? Carnitine, derived from an amino acid, is found in nearly all cells of the body. Its name is derived from the Latin carnus or flesh, as the compound was isolated from meat. Carnitine plays a critical role in energy production. It transports long-chain fatty acids into the mitochondria so they can be […]
What is Diabetic Kidney Disease? Diabetic kidney disease (DKD) is a common microvascular complication of diabetes, is characterized by increased albuminuria level or urinary albumin-to-creatinine ratio, decreased glomerular filtration rate (GFR) or both. Approximately 463 million people were living with diabetes mellitus in 2019 according to the International Diabetes Federation., and this number is projected […]
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26) and human adenovirus type 5 (HAdV-C5) are critical in combating the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. A new study published in the journal Science Advances by an international team of scientists believe they may have found the molecular mechanism that causes […]