What is Vitiligo? Vitiligo is a disease that causes loss of skin color in patches. The discolored areas usually get bigger with time. The condition can affect the skin on any part of the body, and it can also affect the hair and the inside of the mouth. What Causes Vitiligo? Vitiligo occurs when cells […]
Chronic migraine is less common than episodic migraine but is associated with a higher disease burden and cost. Some of these patients suffer from refractory migraines, which are persistent and debilitating headaches that are unresponsive to standard treatments. To be diagnosed with chronic migraine according to the International Classification of Headache Disorders, third edition (ICHD-3), […]
Lung cancer is the most prevalent cancer, with over 2 million new cases reported in 2020 worldwide. It is also the leading cause of cancer-related deaths globally, with 1.79 million reported deaths in 2020. Non-small cell lung cancer accounts for up to 85% of all lung cancer cases, remains the most common type of lung […]
The incidence of prostate cancer increases with age. Although only 1 in 350 men under the age of 50 years will be diagnosed with prostate cancer, the incidence rate increases up to 1 in every 52 men for ages 50 to 59 years. The incidence rate is nearly 60% in men over the age of […]
Olive oil consumption has been shown to have health benefits, especially to lower cardiovascular disease risk, but its associations with total and cause-specific mortality are unclear. In a recently published study in the Journal of the American College of Cardiology, researchers evaluated whether olive oil intake is associated with total and cause-specific mortality in 2 […]
Antimicrobial resistance (AMR) represents one of the greatest challenges facing humankind. It is currently responsible for 700,000 deaths/year. By 2050, 10 million lives/year worldwide will be at risk from drug-resistant infections. Commonly used antibiotics are becoming increasingly ineffective against a growing number of drug-resistant pathogens and the development of new antimicrobial agents has stagnated. There […]
The use of synthetic receptor signaling has the potential to overcome major barriers in the treatment of solid tumors, including the need for chemotherapy by endowing adoptively transferred T cells with new functions. Recently, a team of researchers has found that a synthetic IL-9 receptor allows cancer-fighting T cells to do their work without needing […]
Systemic lupus erythematosus (SLE) is a diffuse connective tissue disease that often affects multiple organs and systems, such as the kidneys, blood system, and nervous system. The disease is more common in women, and patients that have the condition need to take long-term glucocorticoids and immunosuppressants such as cyclophosphamide, mycophenolate mofetil, and other drugs in […]
In order for our immune system to establish an adequate antitumor activity, it requires antigen-specific lymphocytes to undergo activation, expansion, and differentiation, which is determined by the interaction between T cells and antigen-presenting cells (APCs). That is why the control of APC function is a critical step for therapeutic strategies that require T-cell stimulation, with […]
Multiple sclerosis is a major cause of disability, particularly in young adults in temperate climates. Despite much success with drugs that substantially reduce relapse frequency during the initial inflammatory, relapsing-remitting phase, more than half of patients eventually develop non-relapsing, secondary progressive multiple sclerosis one to two decades after the onset of relapsing-remitting multiple sclerosis. This […]