As we age, our folate concentration can decrease, leading to a higher prevalence of a threshold-based medical condition termed serum folate deficiency. The highest folate deficiency rates in the population occur among older adults, with estimated prevalence rates ranging from 5% to 20%. There is evidence that suggests that serum folate deficiency increases the likelihood […]
Lead is a developmental neurotoxicant in wide industrial use that was once broadly distributed in the environment. The extent of the US population exposed in early life to high levels of lead is unknown, as are the consequences for population IQ. Considerable effort is expended to protect today’s children from lead exposure, but there is […]
The purpose of the study according to the researchers is to determine the safety of administering mesenchymal stem cells (MSCs) derived from fat tissue into the cerebrospinal fluid (CSF) of patients with spinal cord injury. The study continues in a phase 1 clinical trial conducted by the Mayo Clinic. All subjects enrolled in the study […]
Traditional medication is not satisfied in rheumatoid arthritis (RA) therapy due to its long-term side effects and failure in cartilage repair. Nanomodification of mesenchymal stem cells (MSCs) holds promise for lifting such hurdles but delivering therapeutic nanomaterials (NPs) into MSCs remains challenging in this new strategy. In a recent study published in the journal Biomaterials, […]
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions and intense pruritus, which often has a profound impact on daily activities and quality of life of patients and their families. There are different therapeutic options for patients with AD that are not controlled with topical treatments, such as cyclosporine, methotrexate, long […]
The factors responsible for increasing length of life are not well understood. Identifying effective interventions to increase lifespan remains a challenge. Clues to unravel the mystery of longevity come from factors identified as contributors to the biology of the aging process such as elevated oxidative stress and mitochondrial dysfunction. The elevated oxidative stress is toxic […]
Parkinson’s disease (PD) is a multifactorial disorder caused by a combination of genetic and environmental factors. Evidence suggests that PD risk factors lead to common pathological processes, including excessive production of reactive oxygen species, axonal pathology, neuroinflammation, and mitochondrial dysfunction. Most PD cases result from an interaction between genetic and environmental risk factors. However, a […]
Studies have suggested that consumption of diets containing fruits, vegetables, fish, nuts and whole grain reduce the risk of cardiovascular disease and type 2 diabetes. Some diets like the Mediterranean or the DASH diets, which consist of many of these healthy food components, substantially improves several risk factors such as insulin resistance, blood lipid profile […]
Breast cancer is the most common cancer in women and the second leading cause of cancer mortality, with more than 2.2 million annual cases and 685,000 estimated deaths globally. In the clinical practice, patients are classified according to the expression of estrogen receptor (ER), progesterone receptor (PR(, amplificacion of human epidermal growth factor receptor 2 […]
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now claimed millions of lives across the world, there has been increased focus on the effects of mild to moderate COVID-19 in the longer term. There is strong evidence of brain-related pathologies, some of which could be a consequence of viral neurotropism or […]