Cambridge scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke. The study, published in Stem Cell Reports, also identifies a drug target to ‘plug’ these leaks […]
To age or not to age! How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes — critically important cellular structures — are crucial for digesting damaged cellular components and pathogens, and maintain stability within cells and tissues. But can they also […]
An international team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer’s and Parkinson’s Diseases. The biosensor can also transmit the results wirelessly to a laptop or smartphone. The device relies on electrical rather than chemical detection, which researchers say is easier to implement and more accurate. Current state of […]
A compound which binds to an inner region of a calcium channel to indirectly regulate it, outperformed gabapentin without troublesome side effects, providing a promising candidate for treating pain. Calcium channels play a central role in pain signaling, in part through the release of neurotransmitters such as glutamate and GABA according to Rajesh Khanna, director […]
Hearing loss affects more than 60 percent of adults aged 70 and older in the United States and is known to be related to an increased risk of dementia. The reason for this association is not fully understood. To better understand the connection, a team of University of California San Diego and Kaiser Permanente Washington […]
A Duke Health analysis of breast cancer in North Carolina showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis. The findings, appearing in the journal Scientific Reports, serve as a national template for assessing the impact of poor environmental quality across different stages […]
Liver fibrosis may occur as a result of liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), and currently, there is no medical treatment to cure liver fibrosis. Doctors often try to address the underlying causes of the diseases, such as obesity and diabetes, and these treatments may lead […]
Doctors often prescribe radiation along with surgery to treat a brain tumor called meningioma that originates in the protective membranes surrounding the brain. But side effects from radiation can be serious, including memory loss and cognitive decline, so it’s important to know which patients really need it. Now, researchers have found a highly accurate way […]
After 40 years of treating metastatic bladder cancer with chemotherapy as a primary treatment, scientists now present a new approach using immunotherapy combinations. The outcomes of these studies are going to revolutionize the landscape of bladder cancer treatment. Traditionally, cisplatin-based chemotherapy has been the standard treatment for bladder cancer patients who are able to tolerate […]
Crohn’s disease is a chronic inflammatory condition that can affect any part of the digestive tract, from the mouth to the anus. It causes inflammation and damage to the digestive system, leading to symptoms such as abdominal pain, diarrhea, weight loss and fatigue and complications such as strictures and fistulas. Crohn’s disease is a lifelong […]