Groundbreaking research published today in Nature Genetics describes the largest-ever study into the genetics of random “round-the-clock” blood glucose levels. The study, involving almost half a million people of diverse backgrounds, describes new DNA variants influencing blood sugar levels measured “at random.” The team of researchers, led by Professor Inga Prokopenko at the University of […]
Scientists have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive to chemotherapy subsequently respond to it. The researchers looked through a chemical library, commonly used for drug discovery, and found two substances that could target the […]
PCOS affects 7-10% of women of childbearing age and is the most common cause of infertility. Women are diagnosed with PCOS if they have two of the following criteria: androgen excess (excess male sex hormones such as testosterone), ovulatory dysfunction and polycystic ovaries. “Our study found geographical differences in PCOS in black and white women, […]
Researchers have discovered a new avenue of cell death in Alzheimer’s disease and vascular dementia. A new study, led by scientists at Oregon Health & Science University and published online in the journal Annals of Neurology, reveals for the first time that a form of cell death known as ferroptosis — caused by a buildup […]
Not only does a lack of sleep make you feel awful, research has shown it impairs the brain. What’s more, sleep loss over long periods can even increase risk for Alzheimer’s and other neurological diseases. Researchers want to understand how sleep deprivation causes this harm. In a new study in ACS’ Journal of Proteome Research, […]
A study of twins shows that having a concussion early in life is tied to having lower scores on tests of thinking and memory skills decades later as well as having more rapid decline in those scores than twins who did not have a concussion, or traumatic brain injury (TBI). The study is published in […]
A large study by researchers at Columbia University Mailman School of Public Health and the Norwegian National Institute of Public Health has identified molecular signatures of gestational inflammation linked to the risk of developing autism spectrum disorder (ASD). These findings, which provide insights into abnormal brain development, could eventually lead to a test to screen […]
Various medical circumstances, including heart attacks and extreme cases of COVID-19, necessitate the use of anticoagulants, medicines that prevent blood clots. But the most commonly used, heparin, can induce potentially fatal side effects by making the blood clots worse rather than better. For the first time, researchers have proposed a side-effect-free anticoagulating treatment that has […]
Patients with melanoma, the most concerning form of skin cancer in which pigment-producing cells start to grow out of control, can benefit from existing immunotherapies, but by far not all of them do. More than 50% of patients do not respond to current immunotherapy drugs and among those that initially respond, many become resistant to […]
Markers that indicate the presence of Parkinson’s disease in patients on average seven years before clinical presentation have been identified by a UCL and Moorfields Eye Hospital research team. The study identified markers of Parkinson’s in eye scans with the help of artificial intelligence (AI). Its analysis of the AlzEye dataset was repeated using the […]