Having high blood pressure in your 30s is associated with worse brain health around age 75, especially for men, according to a new UC Davis study. The research, published this week in JAMA Network Open, compared magnetic resonance imaging (MRI) brain scans of older adults who had high blood pressure between the ages of 30 […]
Lower temperatures have been known to increase longevity for over half a century, but the mechanisms underpinning this increased longevity have remained unclear. Now, scientists have unraveled a mechanism that underpins increased longevity in worms, and shown it to have an effect on human cells. Published in Nature Aging, a study by researchers based in […]
Currently, immunotherapy does not work for everyone. In some patients, tumors shrink or even disappear, while other people do not respond to immunotherapy. Scientists are trying to figure out why different people have different responses to this form of cancer treatment. One factor that may be responsible for the varying immunotherapy responsiveness is the gut […]
A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. If confirmed in additional studies, […]
Inflammatory bowel disease, or IBD, describes Crohn’s disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder — a condition in which the body’s immune system attacks healthy tissues. Its symptoms include diarrhea, rectal bleeding, fatigue, weight […]
Scientists have created balls of cells that resemble embryos and trigger signs of early pregnancy in macaques. The stem-cell-derived blastoids could help researchers understand human embryo development without the ethical dilemmas of using real embryonic cells, according to a study published today in Cell Stem Cell. “The work highlights the amazing potential of stem-cell- based […]
ß cells are critical guardians of the body’s metabolic balance. They are the only cells capable of producing insulin, which regulates blood sugar levels by designating dietary sugar for immediate use or storage. In Type 1 diabetes, ß cells are attacked by the body’s own immune system, rendering them unable to produce insulin. Type 2 […]
Aging, or senescent cells, which stop dividing but don’t die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders. In mice, eliminating senescent cells from aging tissues can restore tissue balance and lead to an increased healthy lifespan. A team led by […]
While new drugs to treat Alzheimer’s disease tend to receive the most public attention, many well-researched ways to care for people with dementia don’t involve medication. A new evaluation compared the cost-effectiveness of four non-drug interventions to the usual care received by people with dementia and found that the interventions not only resulted in a […]
Analyzing changes to DNA in the blood can improve the ability to predict a person’s risk of developing type 2 diabetes within a decade. Scientists looked at the influence of these changes — known as DNA methylation — alongside other risk factors in almost 15,000 people to predict the likelihood of developing the condition years […]