Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc) for short periods of time restores a youthful epigenetic signature to aging cells and extends the life span of a premature aging mouse model. However, the effects of longer-term partial reprogramming in physiologically aging wild-type mice are unknown. As organisms age, it is […]
Therapeutic development for ischemic stroke has previously focused on small molecules, with anti-thrombotic, thrombolytic, and anti-inflammatory mechanisms of action. While approximately 4% of over 430 promising clinical trials for these small molecular therapeutics have reached world markets., ischemic stroke continues to remain a leading cause of death and long-term disability worldwide. Identifying acute parameters which […]
The high prevalence of overweight and obesity is a major public health concern. Obesity is characterized by an excess of body fat that impairs both physical and psychosocial health and well-being. Long-term regulation of body weight is controlled by balancing energy intake with energy expenditure. Understanding the role of specific food items and their impact […]
Radical prostatectomy, surgery to remove the prostate gland, is considered the definitive treatment for localized prostate cancer. Despite the advent of so-called nerve-sparing procedures, the surgery can damage the cavernous nerves, which control erectile function by regulating blood flow to the penis. Erectile dysfunction (ED) after radical prostatectomy has a major impact on the lives […]