The ketogenic diet proved to be effective at controlling polycystic kidney disease (PKD) in the first randomized controlled clinical trial of ketogenic metabolic therapy for PKD. The researchers’ study is published in the journal Cell Reports Medicine. For PKD patients, these findings represent an opportunity to control a genetic disease that leads to a progressive […]
A landmark study has shown that severe asthma can be controlled using biologic therapies, without the addition of regular high-dose inhaled steroids which can have significant side effects. The findings from the multinational SHAMAL study, published in The Lancet, demonstrated that 92% of patients using the biologic therapy benralizumab could safely reduce inhaled steroid dose […]
Microgels form a thin protective shell around a droplet until the temperature rises above 32 degrees. Then the microgels shrink and the droplet dissolves in the surrounding liquid. A study now reveals the underlying mechanism behind this process. The discovery could revolutionize methods of targeting medicines to specific locations within the body. Emulsions consist of […]
Researchers discovered distinct mechanisms controlling different types of immune cells, and found that, by precisely targeting these mechanisms, they could selectively eliminate ‘problematic cells’ and reshape the skin’s immune landscape. Our skin is packed with specialized immune cells that protect against infections and cancer and promote healing. These cells, called tissue-resident T cells or TRM […]
Researchers report that medications that promote slow to moderate weight loss may improve survival rates for people with weight issues who also have knee or hip osteoarthritis. Rapid weight loss prompted by anti-obesity drugs may increase the chance of premature death among people with weight issues who also have knee or hip osteoarthritis, according to […]
A class of type 2 diabetes medications that includes weight loss drugs such as Wegovy and Ozempic might also help prevent colorectal cancer, according to new study published in the journal JAMA Oncology. Researchers report that these drugs, called glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs), help manage diabetes and spur weight loss by lowering […]
Researchers have developed a light-activatable prodrug nanomedicine for age-related macular degeneration (AMD) therapy. Through the intravenous injection of the nanomedicine and application of light irradiation to diseased eyes, anti-angiogenic and photodynamic combination therapy can be activated, offering a minimally invasive alternative for the treatment of AMD and other ocular disorders characterized by abnormal blood vessel […]
Aging is associated with chronic, nonresolving inflammation, or “inflammaging,” that can lead to tissue dysfunction. The resolution of inflammation is an active process that is governed by numerous factors, such as specialized proresolving lipid mediators (SPMs). Recent studies suggest that inflammaging may persist due to an impairment in inflammation-resolution programs and that treatment with SPMs, […]
A groundbreaking study by researchers at Case Western Reserve University suggests a class of medications used to treat type 2 diabetes may also reduce the risk of colorectal cancer (CRC). The findings, published in the journal JAMA Oncology, support the need for clinical trials to determine whether these medications could prevent one of the deadliest […]
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago uncovered a novel mechanism that leads to motor neuron degeneration in spinal muscular atrophy (SMA). This discovery offers a new target for treatment that overcomes important limitations of gene therapy and other […]