Platelet-rich plasma (PRP) is autologous blood plasma with a concentration of platelets well above baseline. The usual concentration of platelets in the blood is approximately 150,000 to 400,000 platelets per cubic microliter. PRP contains 4-7 times the physiologic concentration of platelets. PRP is prepared by centrifugation of blood drawn from the patient before any procedure […]
There is a system in our body, called Renin-Angiotensin-Aldosterone system which is implicated in hypertension, cardiovascular and kidney diseases, where an enzyme, angiotensin II causes vasoconstriction and induces reactive oxygen species (ROS) leading to vascular inflammation and injury. This system is a critical regulator of blood volume and systemic vascular resistance. The 3 components of […]
A migraine is a headache that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. It’s often accompanied by other symptoms, such as naura, vomiting and extreme sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain can be so severe that […]
What is Vitamin C? Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component. It is required for the synthesis […]
Dyslipidemias are a major risk factor for the development of cardiovascular (CV) atherosclerotic diseases. Low-density lipoprotein cholesterol (LDL) is considered the major causative lipid fraction, and lowering it reduces the risk of CV events. LDL is therefore the preferred risk marker in the international guidelines. But with the newly updated guidelines, attention is also recommended […]
Aging is one of the biggest risk factors for chronic diseases, including cardiovascular diseases, metabolic disorders, neurodegenerative pathologies and diverse types of cancers. In recent years, big progress has been made to develop agents to treat individual age-related conditions, such as diabetes, osteoporosis, skeletal fragility and vascular dysfunction. However, the effect has been modest. Several […]
Cardiovascular disease is a major target for many experimental stem cell-based therapies and mesenchymal stem cells (MSCs) are widely used in these therapies. Experimental and clinical observations indicate that transplanted MSCs secrete factors to reduce tissue injury and/or enhance tissue repair. Stem Cells in the Treatment of Acute Myocardial Infarction Acute myocardial infarction (AMI) is […]
Sildenafil, more commonly known as viagra, is a medication used to treat erectile dysfunction in men. It is also used to improve the ability to exercise in adults with pulmonary arterial hypertension. A new study published in the journal Nature Aging looked at the potential of repurposing licensed drugs for the treatment of Alzheimer’s disease […]
The COVID-19 pandemic has taken a heavy toll on the health of populations globally. Risk factors for severe and fatal disease are well recognised, and included male sex, black or Asian ethnic origin, obesity, deprivation and a range of comorbidities including diabetes mellitus, cardiovascular disease, COPD and hypertension. There is growing evidence for population-based studies […]
What is Cerebral Palsy? Cerebral palsy (CP) is a group of disorders that affect movement and muscle tone or posture. It’s caused by damage that occurs to the immature, developing brain, most often before birth. It is one of the leading causes of childhood disability and affects the individual’s development and ability to function. CP […]