A diet containing lots of salt can contribute to increased levels of stress, a new study shows. Scientists found in studies of mice that a high-salt diet increased the levels of a stress hormone by 75 per cent. Experts hope the findings will encourage a review of public health policy around salt consumption, with a […]
Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes. Now, researchers from Osaka University have discovered that stem cell therapy may protect against such side effects. One strategy by which tumor cells evade recognition by the immune system is by […]
Multiple Sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system (CNS). MS affects approximately 2.5 million people worldwide. High prevalence of MS is seen in northern parts of Europe and North America. Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). […]
Aging is characterized by a time-dependent decline in the homeostatic functions of most tissues and organs . In mammals, including humans, aging impairs the skin’s regenerative capacity after injury. This age-associated impaired skin wound healing predisposes patients to non healing chronic disorders that are recognized as age-related complications, including diabetic ulcers, pressure sores, and venous […]
Hip fractures are the most common fractures resulting in hospitalization, particularly among older women. Around 1.6 million cases occur globally each year and rates are increasing, particularly in Europe and Asia. Mobility and independence decrease after hip fracture incidence whilst risk of comorbidities increases, resulting in a reduced health-related quality of life and increased mortality. […]
Olfaction is impaired in 12% of the US population due to causes such as age-related decline, post-viral damage, head trauma, or genetic disorders affecting olfactory neuron function. Impairments in the sense of smell are often permanent and lack treatment options. Recent studies in mice have shown the potential of viral gene therapy to restore olfactory […]
Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc) for short periods of time restores a youthful epigenetic signature to aging cells and extends the life span of a premature aging mouse model. However, the effects of longer-term partial reprogramming in physiologically aging wild-type mice are unknown. As organisms age, it is […]
Therapeutic development for ischemic stroke has previously focused on small molecules, with anti-thrombotic, thrombolytic, and anti-inflammatory mechanisms of action. While approximately 4% of over 430 promising clinical trials for these small molecular therapeutics have reached world markets., ischemic stroke continues to remain a leading cause of death and long-term disability worldwide. Identifying acute parameters which […]
The high prevalence of overweight and obesity is a major public health concern. Obesity is characterized by an excess of body fat that impairs both physical and psychosocial health and well-being. Long-term regulation of body weight is controlled by balancing energy intake with energy expenditure. Understanding the role of specific food items and their impact […]
Radical prostatectomy, surgery to remove the prostate gland, is considered the definitive treatment for localized prostate cancer. Despite the advent of so-called nerve-sparing procedures, the surgery can damage the cavernous nerves, which control erectile function by regulating blood flow to the penis. Erectile dysfunction (ED) after radical prostatectomy has a major impact on the lives […]