Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues. JAK1 is a key protein in the body that supports cell communication and controls the immune system. It is part of a group […]
Researchers at Nagoya University’s Graduate School of Bioagricultural Sciences and the National Institute of Physiological Sciences in Japan have demonstrated how a specific type of neuron in the brain affects the release of hormones that control ovarian function, such as follicular development and ovulation in females. Kisspeptin neurons in the brain regulate the release of […]
Scientists have identified a protein in the visual system of mice that appears to be key for stabilizing the body’s circadian rhythms by buffering the brain’s response to light. Scientists have long known that most living things have a circadian “clock,” a set of biological rhythms that operate on about a 24-hour cycle and that […]
Scientists from Scripps Research have developed a new method to examine how proteins interact with drug-like small molecules in human cells — revealing critical information about how to potentially target them therapeutically. The strategy uses a combination of chemistry and analytical techniques to reveal the specific places where proteins and small molecules bind together. The […]
A new study, led by experts at the University of Nottingham found that the risk of stomach bleeding caused by using aspirin long-term, can be reduced with a short course of antibiotics, potentially improving the safety of aspirin when used to prevent heart attacks, strokes and possibly some cancers. Aspirin in low doses is a […]
A new study has shown that women who are taking the oral contraceptive pill are less likely to report depression. The research, which analyzed data from 6,239 women in the United States aged 18-55 years old, found that the prevalence of major depression amongst users of the oral contraceptive pill (OCP) was significantly lower, at […]
New research indicates that the eating disorder anorexia nervosa is associated with being an early riser, unlike many other disorders that tend to be evening-based such as depression, binge eating disorder and schizophrenia. Previous research has suggested a possible connection between eating disorders and the body’s internal clock, or circadian clock, which controls a wide […]
A cochlear implant enables people with severe hearing loss to hear again. An audiologist adjusts the device based on the user’s input, but this is not always easy. Think of children who are born deaf or elderly people with dementia. They have more difficulty assessing and communicating how well they hear the sounds, resulting in […]
Patients with long COVID can exhibit a reduction in circulating levels of the neurotransmitter serotonin, according to a new research. The mechanisms that cause long COVID have not been studied in depth, and treatments that are widely effective in reducing these long-term symptoms have not yet been developed. “Many aspects of the basic biology underlying […]
Inflammatory processes are associated with a large range of human diseases, including rheumatic diseases and allergies. Protein biomarkers are measurable molecules that can have a prognostic value in patients, be used to diagnose disease, or indicate severity of disease. However, the causal relationship between a protein biomarker and inflammatory diseases is generally unknown. The protein […]