Scientists in Melbourne have designed a new type of oral capsule that could mean pain-free delivery of insulin and other protein drugs. “These types of drugs (protein) are typically administered with an injection — thousands of diabetics in Australia need insulin injections up to several times a day, which can be unpleasant for the patient […]
High blood pressure, also known as hypertension, occurs when the force of blood pushing against the walls of blood vessels is consistently too high The current blood pressure guidelines classify hypertension as a blood pressure reading of 130/80 mm Hg or higher. The blood pressure criteria for this study are slightly different from the ACC/AHA […]
Peanuts cause severe, sometimes fatal, reactions in an estimated 1.1 percent of the global population. “Our approach is unique because our inhibitor starts working before the allergen has a chance to trigger an allergic reaction,” said Başar Bilgiçer, professor of chemical and biomolecular engineering, “Our collaboration with Dr. Mark Kaplan at Indiana University School of […]
The Epstein-Barr virus causes infectious mononucleosis and similar ailments, though often there are no symptoms. Most infections are mild and pass, but the virus persists in the body, becoming latent or inactive, sometimes reactivating. Long-term latent infections are associated with several chronic inflammatory conditions and multiple cancers. In a recent paper it was described for […]
Rutgers researchers traced this link from mother to child in mice with an experiment that began by letting some mice get obese on unlimited high-fat food during pregnancy and breastfeeding while keeping others slim on limitless healthy food. They found that mice born to obese mothers stay slim in adulthood on unlimited healthy food but […]
Activation of a receptor with no known function in the brain reduces excessive alcohol use and the pain of withdrawal, according to preclinical research in male rats. GPR139 is an orphan G protein-coupled receptor that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function […]
Exposure to female odors and pheromones causes weight loss and extends the life spans of mice, which may have implications for humans. “Our studies show that female odors slow the sexual development of female mice, but consequently extends their lifespan. And we also show that the smell of females can increase male mouse energy expenditure, […]
Researchers have identified a factor that acts like a molecular switch in the skin of baby mice that controls the formation of hair follicles as they develop during the first week of life. The switch is mostly turned off after skin forms and remains off in adult tissue. When it was activated in specialized cells […]
By stirring crosstalk among skin cells that form the roots of hair, researchers report they have regrown hair strands on damaged skin. The study examined the effect of distinct signaling pathways in damaged skin of laboratory mice. Experiments focused on cells called fibroblasts that secrete collagen, the structural protein most responsible for maintaining the shape […]
Houston Methodist Research Institute researchers used an implantable nanofluidic device they invented to deliver CD40 monoclonal antibodies (mAb), a promising immunotherapeutic agent, at a sustained low-dose via the nanofluidic drug-eluting seed (NDES). The result, found in murine models, was tumor reduction at a fourfold lower dosage than traditional systemic immunotherapy treatment. The NDES device consists […]